Regenerative medicine/Stem Cells and Exosomes


Stem Cells and Exosomes, the latest regenerative therapy revolution is here now with Dr. Bregman!!

Regenerative medicine aims to improve the regeneration of damaged, malfunctioning, and missing tissue and organs. Mounting evidence supports that stem cell therapies may be promising in this field on the basis of potential therapeutic use of stem cells in damaged areas such as spinal cord injury, retina diseases, and other tissues in the body.  In addition, stem cells-based therapy may be a prospective way for diseases that are irreversible and incurable at present. Specifically, regenerative medicine contains two goals: one is efficiently and safely transferring stem cells into injured tissues, which may replace the need for surgery in the near future; the other is to develop strategies in order to improve the regenerative potential and function of adult stem cells residing in various organs.   In the last decade, numerous preclinical studies confirmed the therapeutic potentials of stem cells. Stem cells involving embryonic stem cells (ESCs), induced pluripotent stem cells (iPSCs), and adult stem cells manifest respective merits and drawbacks. Some types of stem cells are being evaluated in clinical trials with promising results. These stem cells such as mesenchymal stem cells (MSCs) are relatively safe, but therapeutic strategies avoiding direct use of living stem cells are more likely to provide a safer way to prevent disease progression. Although direct and indirect mechanisms such as growth factors and cytokines have accounted for the therapeutic effects, paracrine secretion seems to play a predominant role. A key component of paracrine secretion is extracellular vesicles (EVs), particularly the exosome fraction that mainly contributes to the action of stem cells in which genetic information can be horizontally transferred between stem cells and tissue-injured cells. On the basis of the ability of microvesicles (MVs) to mimic stem cell properties, it is speculated that stem cell-derived MVs especially exosomes represent a relevant therapeutic option in regenerative medicine.

Exosomes, a group of vesicles originating from the multivesicular bodies (MVBs), are released into the extracellular space when MVBs fuse with the plasma membrane. Numerous studies indicate that exosomes play important roles in cell-to-cell communication, and exosomes from specific cell types and conditions display multiple functions such as exerting positive effects on regeneration in many tissues. It is widely accepted that the therapeutic potential of stem cells may be mediated largely by the paracrine factors, so harnessing the paracrine effects of stem and progenitor cells without affecting these living, replicating, and potentially pluripotent cell populations is an advantage in terms of safety and complexity. Increased evidence indicates that exosomes might be the main components of paracrine factors.

To put it simply Exosomes are the more efficient way to deliver the necessary proteins and signals to injured or damaged cells to regenerate or heal.  Unfortunately, this therapy is NOT covered by insurance and is relatively expensive. But if looking to avoid surgery or nothing else has worked it is a great option for people to consider, the future is here now with Dr. Bregman.


If you are getting older and injuries just don’t heal as quick or your tendinitis won’t go away then Exosome treatment might be for you.  Do you have arthritis and you don’t want surgery or do not want to keep taking prescription medication that has side effects, then Exosome therapy might be for you.  It can be given into joints including the knee and ankle and foot. It can be given IV for a more overall effect and even can be used intra-nasally. For athletes this new therapy can allow you to train harder and push through plateaus like never before!

Bregman Foot-Ankle & Nerve Center
7150 West Sunset Rd., #110
Las Vegas, NV 89113
Phone: 702-703-2526
Fax: 877-679-7742
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